So far, studies on the association between the glucose transporter 1 (GLUT1) rs841853 polymorphism and type 2 diabetes mellitus (T2DM) risk have generated considerable controversy. The present study was performed to clarify the association of this genetic variation with T2DM.
A comprehensive literature search of electronic databases was conducted to obtain articles focused on the relationship between the GLUT1 rs841853 polymorphism and T2DM, followed by a systemic meta-analysis.
Fourteen articles and 19 individual studies were included for analysis. Main analyses revealed extreme heterogeneity and random effect pooled odds ratios (OR) were weakly significant in allele contrast (OR 1.28; 95% confidence interval [CI] 1.01, 1.63; P = 0.04) and dominant model (OR 1.52; 95% CI 1.19, 1.94; P = 0.0008) for T allele. Subgroup analyses for Caucasians showed marginal positive results in the dominant model. However, analyses for Asians yielded an obvious relationship to T2DM risk in all genetic models. Interestingly, T allele even seemed to be a protective factor against the development of T2DM in Blacks in allele contrast. Sensitivity analyses did not alter materially for most comparisons and no publication bias was found in this meta-analysis.
The results of the present meta-analysis provide evidence that the GLUT1 rs841853 polymorphism may confer increased susceptibility to T2DM in Asians. However, there is no currently available strong evidence supporting the association between this genetic variation and T2DM in Caucasians, Blacks, or the overall population.
本Meta分析共纳入14篇文献的19个独立研究。主分析提示各独立研究之间存在极度异质性，故应用随机效应模型进行效应量的合并，结果提示T等位基因与T2DM的易感性相关 [等位基因对比模型：OR=1.28，95% CI（1.01, 1.63），P = 0.04；显性模型：OR=1.52，95% CI （1.19, 1.94），P = 0.0008]。对高加索人群进行亚组分析结果提示，仅在显性模型中T等位基因与T2DM的易感性相关。然而，对亚洲人群的亚组分析则显示，在所有的基因模型中T等位基因与T2DM的易感性均相关。有趣的是，在对黑人进行亚组分析的过程中发现，T等位基因似乎是T2DM的保护因素。敏感性分析并没有改变大多数比较的结果，本Meta分析不存在发表偏移。