Association between glucose transporter 1 rs841853 polymorphism and type 2 diabetes mellitus risk may be population specific (葡萄糖转移酶1的rs841853基因多态性与2型糖尿发生风险的关系可能具有人群特异性)



Wenpeng Cui, Department of Nephrology, Second Hospital, Jilin University, 218 Ziqiang Street, Changchun, Jilin 130041, China.

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So far, studies on the association between the glucose transporter 1 (GLUT1) rs841853 polymorphism and type 2 diabetes mellitus (T2DM) risk have generated considerable controversy. The present study was performed to clarify the association of this genetic variation with T2DM.


A comprehensive literature search of electronic databases was conducted to obtain articles focused on the relationship between the GLUT1 rs841853 polymorphism and T2DM, followed by a systemic meta-analysis.


Fourteen articles and 19 individual studies were included for analysis. Main analyses revealed extreme heterogeneity and random effect pooled odds ratios (OR) were weakly significant in allele contrast (OR 1.28; 95% confidence interval [CI] 1.01, 1.63; P = 0.04) and dominant model (OR 1.52; 95% CI 1.19, 1.94; P = 0.0008) for T allele. Subgroup analyses for Caucasians showed marginal positive results in the dominant model. However, analyses for Asians yielded an obvious relationship to T2DM risk in all genetic models. Interestingly, T allele even seemed to be a protective factor against the development of T2DM in Blacks in allele contrast. Sensitivity analyses did not alter materially for most comparisons and no publication bias was found in this meta-analysis.


The results of the present meta-analysis provide evidence that the GLUT1 rs841853 polymorphism may confer increased susceptibility to T2DM in Asians. However, there is no currently available strong evidence supporting the association between this genetic variation and T2DM in Caucasians, Blacks, or the overall population.



目前有许多研究对葡萄糖转移酶1(GLUT1) 的rs841853基因多态性与2型糖尿病(T2DM)易感性之间的关系进行了探讨,然而结果不尽相同。本研究旨在明确这一基因突变与T2DM易感性之间的关系。


我们对电子数据库进行系统的文献检索,检索探讨GLUT1 rs841853基因多态性与T2DM易感性之间关系的文献,之后提取数据进行Meta分析。


本Meta分析共纳入14篇文献的19个独立研究。主分析提示各独立研究之间存在极度异质性,故应用随机效应模型进行效应量的合并,结果提示T等位基因与T2DM的易感性相关 [等位基因对比模型:OR=1.28,95% CI(1.01, 1.63),P = 0.04;显性模型:OR=1.52,95% CI (1.19, 1.94),P = 0.0008]。对高加索人群进行亚组分析结果提示,仅在显性模型中T等位基因与T2DM的易感性相关。然而,对亚洲人群的亚组分析则显示,在所有的基因模型中T等位基因与T2DM的易感性均相关。有趣的是,在对黑人进行亚组分析的过程中发现,T等位基因似乎是T2DM的保护因素。敏感性分析并没有改变大多数比较的结果,本Meta分析不存在发表偏移。


本Meta分析的结果表明,在亚洲人群中GLUT1 rs841853基因多态性与发生T2DM的风险之间的具有相关性。然而在总体人群、高加索人群以及黑人中尚缺乏足够证据证实两者之间的相关性。