Relationship between major depression and insulin resistance: Does it vary by gender or race/ethnicity among young adults aged 20–39 years? (严重抑郁症与胰岛素抵抗的关系:在20–39岁的青年成人中这种关系是否会受到性别或者种族/族裔的影响?)

Authors

  • Qiuhua Shen,

    Corresponding author
    1. School of Nursing, University of Kansas, Kansas City, Kansas, USA
    • Correspondence

      Qiuhua Shen, School of Nursing, Mailstop 4043, University of Kansas, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.

      Tel: +1 913 588 4336

      Fax: +1 913 588 1660

      Email: qshen@kumc.edu

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  • Sandra Bergquist-Beringer

    1. School of Nursing, University of Kansas, Kansas City, Kansas, USA
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Abstract

Background

To examine the relationship between major depression and insulin resistance by gender and race/ethnicity among young adults without diabetes mellitus.

Methods

Secondary analyses of cross-sectional data from the National Health and Nutrition Examination Survey 1999–2008 were performed (n = 2265). Major depression was measured by the Composite International Diagnostic Interview and the Patient Health Questionnaire 9. Insulin resistance was measured by the homeostasis model assessment of insulin resistance. Multivariate logistic regression analyses adjusted for risk factors of insulin resistance were conducted.

Results

There was a significant negative association between major depression and insulin resistance among men. For women, no significant association was found. There was no significant interaction between race/ethnicity and major depression on insulin resistance (Wald χ2 = 4.2927, P = 0.2315). Body mass index (BMI) and waist circumference (WC) were significantly associated with insulin resistance among both men (odds ratio [OR] 1.255, 95% confidence interval [CI] 1.195–1.318 for BMI; OR 1.095, 95% CI 1.076–1.115 for WC) and women (OR 1.220, 95% CI 1.182–1.260 for BMI; OR 1.084, 95% CI 1.064–1.105 for WC).

Conclusions

There are gender differences in the relationship between major depression and insulin resistance among adults aged 20–39 years. No evidence was found to support the role of race/ethnicity in this relationship. Health care professionals should be aware of risk factors for insulin resistance and develop interventions to help prevent the progression of insulin resistance to type 2 diabetes mellitus.

摘要

背景

在没有糖尿病的青年成人中调查严重抑郁症与胰岛素抵抗的关系是否会受到性别与种族/族裔的影响。

方法

对来自1999–2008年全国健康与营养调查研究的横截面数据进行二次分析(n=2265)。根据复合国际诊断访问表与患者健康问卷表9来判断严重抑郁症。通过胰岛素抵抗的稳态模型评估来判断胰岛素抵抗。通过多因素logistic回归分析对胰岛素抵抗的危险因素进行校正。

结果

对于男性来说,严重抑郁症与胰岛素抵抗的关系呈显著负相关。对于女性来说,没有发现显著性相关。种族/族裔与严重抑郁症对胰岛素抵抗的影响之间没有显著的相互作用(Wald χ2 = 4.2927,P = 0.2315)。无论是男性(BMI的优势比[OR]为1.255, 95%置信区间[CI] 为1.195–1.318;WC的OR为1.095,95% CI为1.076–1.115)还是女性(BMI的OR为1.220,95% CI为1.182–1.260 ;WC的OR为1.084,95% CI为1.064–1.105),BMI以及腰围与胰岛素抵抗之间都有显著性的相关关系。

结论

在20–39岁的成人中,严重抑郁症与胰岛素抵抗之间的关系具有性别差异。没有发现有证据支持种族/族裔对这种关系有影响。健康护理专业人员应该知道胰岛素抵抗的危险因素,并且制定出干预措施以防止胰岛素抵抗进展为2型糖尿病。

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