Diabetes and cancer relationships (糖尿病与肿瘤的关联性)

Authors

  • Tiange Wang,

    1. Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai, China
    2. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    3. E-Institute of Shanghai Universities, Shanghai, China
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  • Guang Ning,

    1. Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai, China
    2. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    3. E-Institute of Shanghai Universities, Shanghai, China
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  • Zachary Bloomgarden

    Corresponding author
    1. Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    • Correspondence

      Zachary Bloomgarden, Department of Medicine, Mount Sinai School of Medicine, 35 East 85th Street, New York, NY 10028, USA.

      Tel: +1 212 879 5933

      Fax: +1 212 861 7429

      Email: zbloom@gmail.com

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Abstract

Diabetes and cancer are both heterogeneous and multifactorial diseases with tremendous impact on health worldwide. Epidemiologic evidence suggests that certain malignancies may be associated with diabetes, as well as with diabetes risk factors and, perhaps, with certain diabetes treatments. Numerous biological mechanisms could account for these relationships. Insulin-like growth factor (IGF)-1, IGF-2, IGF-1 receptors, insulin, and the insulin receptor play roles in the development and progression of cancers. Although evidence from randomized controlled trials does not support or refute associations of diabetes and its treatments with either increased or reduced risk of cancer incidence or prognosis, consideration of malignancy incidence rates and the magnitude of the trials that would be required to address these issues explains why such studies may not be readily undertaken.

摘要

糖尿病与肿瘤都是异质性的多因素疾病,严重影响全球人类健康。流行病学证据揭示,某些恶性肿瘤与糖尿病、糖尿病危险因素和某些降糖药物密切相关。多种生物学机制可以解释这些关联。胰岛素样生长因子(IGF)-1、IGF-2、IGF-1受体、胰岛素和胰岛素受体均参与了某些肿瘤的发生和发展。尽管众多随机对照试验尚未得出糖尿病及其治疗药物影响肿瘤发生和发展的明确结论,恶性肿瘤的发病率以及解决该问题所需的研究规模决定了该类研究的实施难度。

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