Willingness to take drugs to prevent serious chronic diseases (自愿服用药物以预防严重的慢性疾病)

Authors


Abstract

Background

The aim of this study was to determine an individual's willingness to take a preventive therapy for each of two chronic diseases (type 2 diabetes [T2D] and dementia) when provided with varying likelihoods of acquiring the disease.

Methods

After reading a description of two chronic diseases (i.e. T2D and dementia), 345 student volunteers at McMaster University rated their likelihood of taking a drug that could halve their chance of developing each disease, assuming a 1-year risk of developing the disease of 50%, 25%, and 10%. A five-point Likert scale was used to collect responses.

Results

Assuming an annual incidence of 50%, 27% of respondents were neither likely nor very likely to take a therapy that halved the annual incidence of T2D and 13% were neither likely nor very likely to take a therapy that halved the annual incidence of dementia. Higher quoted incidence rates of the disease and a personal history of a chronic illness significantly increased willingness to take such therapy.

Conclusions

A high proportion of young educated adults have ambivalent or negative attitudes regarding the use of pharmacological therapy to prevent serious health outcomes even when the absolute 1-year risk of these outcomes is very high.

摘要

背景

本研究的目的是假设当一个人具有多个疾病(2型糖尿病与痴呆)的危险因素时,测定其服用预防性治疗药物以预防这两种慢性疾病的意愿。

方法

在阅读完两种慢性疾病(亦即2型糖尿病与痴呆)的相关说明后,345名自愿参加研究的麦克马斯特大学学生对自己服用一种药物的可能性进行分级,假定1年发生疾病的风险为50%、25%与10%,这种药物能够将他们发生每一种疾病的机会减半。使用五点李克特量表来收集他们的反应。

结果

假定年发病率为50%,27%的应答者既不是有可能也不是非常有可能服用一种可以将2型糖尿病年发病率减半的治疗药物,13%的应答者既不是有可能也不是非常有可能服用一种可以将痴呆的年发病率减半的治疗药物。更高的疾病发病率以及慢性疾病个人史都可以显著地增加服用这种治疗药物的意愿。

结论

较高比例的受过教育的青年成人对待是否使用治疗药物预防严重健康问题的态度是矛盾的或者消极的,即使这些问题的1年绝对发生风险非常高。

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