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Keywords:

  • calcineurin inhibitors;
  • food–drug interaction;
  • isoniazide;
  • methotrexate;
  • rheumatoid arthritis

Abstract

Various medications are used for the treatment of rheumatoid arthritis (RA). Food–drug interactions may occur with concomitant ingestion of particular food. For example, methotrexate (MTX), the anchor drug in the therapeutic strategy against RA, is an antifolate agent. Excessive presence or absence of dietary folic acid may regulate MTX metabolism, possibly leading to unexpected adverse reactions. In this review, we focus on MTX, isoniazide and calcineurin inhibitors, and the implications of potential food–drug reactions in rheumatology, suggesting the important role of nutritional evaluations in RA patients.