Low body mass index is associated with impaired quality of life in patients with rheumatoid arthritis
Article first published online: 23 MAY 2013
© 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd
International Journal of Rheumatic Diseases
Volume 16, Issue 3, pages 297–302, June 2013
How to Cite
Fukuda, W., Omoto, A., Ohta, T., Majima, S., Kimura, T., Tanaka, T., Kohno, M. and Kawahito, Y. (2013), Low body mass index is associated with impaired quality of life in patients with rheumatoid arthritis. International Journal of Rheumatic Diseases, 16: 297–302. doi: 10.1111/1756-185X.12079
- Issue published online: 11 AUG 2013
- Article first published online: 23 MAY 2013
- arm muscle area (AMA);
- body mass index (BMI);
- muscle protein;
- quality of life (QOL);
- rheumatoid arthritis (RA);
- rheumatoid chachexia
To investigate the relationship between quality of life (QOL) and rheumatoid chachesia, malnutrition in patients with rheumatoid arthritis (RA).
EuroQol Group 5-Dimension Self-Report Questionnaire (EQ5D) and Japanese Health Assessment Questionnaire (JHAQ) scores, body mass index (BMI), arm muscle area (AMA) and clinical indicators were measured in 385 RA patients. One-way analysis of variance for obtained data was conducted among three groups: 131 with low BMI (< 20), 163 with moderate (20–25) and 91 with high BMI (≥25). Then multiple regression analyses for JHAQ and EQ5D scores with nutritional and clinical indicators as independent variables were performed.
EQ5D and JHAQ scores were significantly lower and higher, respectively, in the low BMI group than those in the moderate BMI group. Clinical indicators including doses of corticosteroid were similar among the three groups except for disease duration. Disease activity score (DAS) 28, disease duration, C-reactive protein and AMA were significant variables in the regression model for EQ5D.
Low BMI deteriorates the QOL of RA patients. Muscle protein loss apparently leads to a reduction in BMI and QOL.