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Effects of sesame seed supplementation on clinical signs and symptoms in patients with knee osteoarthritis

Authors

  • Bina Eftekhar Sadat,

    1. Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Mahdieh Khadem Haghighian,

    Corresponding author
    1. Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
    • Correspondence: Dr Mahdieh Khadem Haghighian, Student Research Committee, Faculty of Health & Nutrition, Tabriz University of Medical Sciences, Attar Neishaboory Ave, Golgasht St., Tabriz, Iran. Email: mahdieh_khadem@yahoo.com

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  • Beitollah Alipoor,

    1. Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Aida Malek Mahdavi,

    1. Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Mohammad Asghari Jafarabadi,

    1. Traffic Injury Prevention Research Center, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
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  • Abdolvahab Moghaddam

    1. Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Abstract

Aim

Up to now there have been no human studies to evaluate the effect of sesame (Sesamum indicum L.) in osteoarthritis patients; this study was designed to assess the effect of administration of sesame on clinical signs and symptoms in patients with knee osteoarthritis (OA).

Methods

Fifty patients with knee OA referred to the only specialty and subspecialty orthopedic centers in the north-west of Iran, were selected and divided into two groups, namely control and sesame groups. Twenty-five patients in the control group received standard treatment while 25 patients in the sesame group received 40 g/day sesame by oral administration during 2 months of the study along with standard drug therapy. The KOOS Questionnaire, Timed Up and Go (TUG) and Visual Analog Scale (VAS) tests were used for clinical assessments.

Results

There was significant difference in pain intensity between the two groups (P = 0.004) after treatment. The mean score of the KOOS Questionnaire in both treatment and control groups was significantly increased (P = 0.001 and P = 0.001, respectively) compared with baseline. The mean score of the TUG Questionnaire in both treatment and control groups was significantly decreased (P = 0.001 and P = 0.001, respectively) compared with baseline. There was significant difference in post-treatment scores of the KOOS Questionnaire (P = 0.009) and TUG (P = 0.002) between the two groups.

Conclusions

The present study showed a positive effect of sesame in improving clinical signs and symptoms in patients with knee OA and indicated the fact that sesame might be a viable adjunctive therapy in treating OA.

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