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IgG4-related disease in Singapore: a description of two cases and review of the literature


Correspondence: Dr Warren Weng Seng Fong, Registrar, Department of Rheumatology and Immunology, Block 6 Level 9, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.



We describe a 42-year-old man who presented with painless obstructive jaundice, organomegaly and lymphadenopathy. Biopsy of the ampulla of Vater revealed the presence of increased populations of plasma cells which stained positively for immunoglobulin G4. He was treated with prednisolone and demonstrated significant clinical improvement 1 month later. A further case is described and a review of the literature is also provided.