Bordetella holmesii: initial genomic analysis of an emerging opportunist

Authors


  • An inexpensive draft genome of Bordetella holmesii reveals unsuspected phylogeny, virulence factors of this emerging pathogen, and a predicted toluene-4-monoxygenase.

Abstract

Bordetella holmesii is an emerging opportunistic pathogen that causes respiratory disease in healthy individuals and invasive infections among patients lacking splenic function. We used 16S rRNA gene analysis to confirm B. holmesii as the cause of bacteremia in a child with sickle cell disease. Semiconductor-based draft genome sequencing provided insight into B. holmesii phylogeny and potential virulence mechanisms and also identified a toluene-4-monoxygenase locus unique among bordetellae.

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