The manuscript deals with an important topic in mucosal immunology - the mechanism of activity by which probiotics protect against rotavirus (RV)-induced diarrhea. The data shows that in an animal model, administration of Lactobacillus rhamnosus GG (LGG) is associated with higher levels of soluble IgA, and modulation of production of cytokines IFN-[gamma] and TNF-α is observed. These findings may contribute to improve prevention and treatment of RV-induced diarrhea in humans.
Protective effects of Lactobacillus rhamnosus GG against human rotavirus-induced diarrhoea in a neonatal mouse model
Article first published online: 11 MAR 2013
© 2013 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
Pathogens and Disease
Volume 67, Issue 3, pages 184–191, April 2013
How to Cite
Zhang, Z., Xiang, Y., Li, N., Wang, B., Ai, H., Wang, X., Huang, L. and Zheng, Y. (2013), Protective effects of Lactobacillus rhamnosus GG against human rotavirus-induced diarrhoea in a neonatal mouse model. Pathogens and Disease, 67: 184–191. doi: 10.1111/2049-632X.12030
- Issue published online: 8 APR 2013
- Article first published online: 11 MAR 2013
- Accepted manuscript online: 11 FEB 2013 11:10AM EST
- Manuscript Revised: 29 JAN 2013
- Manuscript Accepted: 29 JAN 2013
- Manuscript Received: 17 AUG 2012
- Shenzhen Bureau of Science Technology & Information. Grant Number: JC200903180532A
- RFDP. Grant Number: 20090002120055
- Nanshan district Bureau of Science Technology
- Wuhan Bureau of Science Technology. Grant Number: 201050231036
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