Combination antiretroviral therapy has forever changed the outcome of AIDS, transforming it from an untreatable, fatal syndrome into a manageable chronic condition. However, the search for new therapeutic targets is always on, because of the issue of mutation in the virus determining resistance to all drugs in use. Esposito et al. describe the activities of compounds that they tested against RNase H, a viral enzyme that has not been fully exploited as a target for antiretrovirals. Their results will be relevant to the development of new drugs to treat HIV infection.
Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities
Version of Record online: 2 JUL 2013
© 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved
Pathogens and Disease
Volume 68, Issue 3, pages 116–124, August 2013
How to Cite
Esposito, F., Sanna, C., Del Vecchio, C., Cannas, V., Venditti, A., Corona, A., Bianco, A., Serrilli, A. M., Guarcini, L., Parolin, C., Ballero, M. and Tramontano, E. (2013), Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities. Pathogens and Disease, 68: 116–124. doi: 10.1111/2049-632X.12051
- Issue online: 18 JUL 2013
- Version of Record online: 2 JUL 2013
- Accepted manuscript online: 12 JUN 2013 07:02AM EST
- Manuscript Accepted: 5 JUN 2013
- Manuscript Revised: 25 MAR 2013
- Manuscript Received: 6 FEB 2013
- RAS. Grant Number: LR 7/2007 CRP-24915
- Provincia dell'Ogliastra
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