In this paradigm shifting study, the authors confirm that chlamydiae can efficiently infect the gastrointestinal tract (of mice in this case but potentially all hosts, including humans) and remain there as chronic infections for significant lengths of time. While the host might mount an initial immune response, this does not eliminate the infection. This “silent” GI tract infection by Chlamydia could result in subsequent reinfections, not only of the gastrointestinal tract but also the genital tract, altering the way we view host immune response to this pathogen.
Chlamydial infection of the gastrointestinal tract: a reservoir for persistent infection
Article first published online: 10 JUL 2013
© 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved
Pathogens and Disease
Volume 68, Issue 3, pages 88–95, August 2013
How to Cite
Yeruva, L., Spencer, N., Bowlin, A. K., Wang, Y. and Rank, R. G. (2013), Chlamydial infection of the gastrointestinal tract: a reservoir for persistent infection. Pathogens and Disease, 68: 88–95. doi: 10.1111/2049-632X.12052
- Issue published online: 18 JUL 2013
- Article first published online: 10 JUL 2013
- Accepted manuscript online: 12 JUN 2013 07:02AM EST
- Manuscript Accepted: 4 JUN 2013
- Manuscript Revised: 3 JUN 2013
- Manuscript Received: 6 MAY 2013
- Arkansas Children's Hospital Research Institute and the Arkansas Biosciences Institute
- Marion B. Lyon New Scientist Development Award. Grant Number: U19 AI084044
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