In this paper further evidence of the important role of the chlamydial plasmid in virulence is provided. In both the respiratory and urogenital tract sites, the plasmid-containing version of Chlamydia trachomatis was more virulent than the non-plasmid strain, when analysed in the mouse model. While this has previously been shown with the mouse strain of Chlamydia, this is the first report showing similar virulence characteristics of the human C. trachomatis strains.
Plasmid deficiency in urogenital isolates of Chlamydia trachomatis reduces infectivity and virulence in a mouse model
Version of Record online: 10 SEP 2013
© 2013 The Authors. Pathogens and Disease published by John Wiley & Sons Ltd on behalf of the Federation of European Microbiological Societies.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Pathogens and Disease
Volume 70, Issue 1, pages 61–69, February 2014
How to Cite
Sigar, I. M., Schripsema, J. H., Wang, Y., Clarke, I. N., Cutcliffe, L. T., Seth-Smith, H. M.B., Thomson, N. R., Bjartling, C., Unemo, M., Persson, K. and Ramsey, K. H. (2014), Plasmid deficiency in urogenital isolates of Chlamydia trachomatis reduces infectivity and virulence in a mouse model. Pathogens and Disease, 70: 61–69. doi: 10.1111/2049-632X.12086
The copyright line for this article was changed on 12 August after original online publication.
- Issue online: 12 FEB 2014
- Version of Record online: 10 SEP 2013
- Accepted manuscript online: 23 AUG 2013 09:02AM EST
- Manuscript Revised: 19 AUG 2013
- Manuscript Accepted: 19 AUG 2013
- Manuscript Received: 19 JUL 2013
- Midwestern University intramural funds and by Wellcome Trust. Grant Numbers: 091296, 098051
|fim12086-sup-0001-TableS1.tif||image/tif||181K||Table S1. Single nucleotide polymorphisms (SNPs) in E/SW2 compared to E/SW3.|
|fim12086-sup-0001-TableS2.tif||image/tif||139K||Table S2. Single nucleotide polymorphisms (SNPs) in F/SWFP compared to F/SW4.|
|fim12086-sup-0001-TableS3.tif||image/tif||21K||Table S3. Pseudogenes in the genomes of the strains studied.|
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