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Fig. S1 dilp1, dilp2, dilp3 anddilp5 mRNA measured from fat body, midgut, ovary, brain and head carcass.

Fig. S2 DistribuLon of dilp6 reporter inadipose tissue and brain.

Fig. S3 Lifespan of dilp6over-expression using ubiquitous drivers: (A)Tub-GeneSwitch-Gal4, (B) da-GeneSwitch-Gal4, (C) neuronal Elav-GeneSwitch-Gal4.

Fig. S4 Lifespan of dilp6 silencingusing ubiquitous drivers: (A)Tub-GeneSwitch-Gal4; and fat body (B)S32-GeneSwitch-Gal4, (C)S106-GeneSwitch-Gal4.

Fig. S5 Specificity of anL-DILP2 and anL-DILP5 anLbodies in EIA.

Fig. S6 Upon 2% and 8% yeast diet,qRT-PCR verifies the inducLon of dilp6 byUAS-dilp6 (A,B), and dilp6 knock-down byRNAi (C).

Fig. S7 sNPF transcripts measured in flies withubiquitous and Lssue-specific dilp6overexpression.

Fig. S8 S106-gal4 does not induce transgene expression without RU.

Fig. S9 RU486 alone does not induce aging or metabolic phenotypes.

Fig. S10 Model for DILP6 to regulate lifespan by repressing DILP produced in the brain.

Fig. S11 Mortality rate (esLmated as–ln(ln(px)) for survival plots of text figure 2.

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