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Data S1 Sampling and genotyping.

Fig. S1 Protocol diagram for the inclusion of the participants.

Fig. S2 Signaling pathway of βAR/AC/ERK.

Fig. S3 Genotypic effects of SNPs rs1042718 and rs1042719 on BMI, systolic blood pressure and diastolic blood pressure in the oldest-old and young subjects.

Table S1 Characteristics of 96 centenarians and 96 young individuals from population 1.

Table S2 Primers list for genotyping.

Table S3 Allelic association of ADCY5, ADCY6, MAPK1, ADRB1 and ADRB2 with longevity in 96 centenarians and 96 young individuals from population 1.

Table S4 Allelic association of ADRB2 with longevity in females.

Table S5 Interaction of ADRB2 with gender in combined population.

Table S6 Enrichment of MAF with increased deathage.

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