These authors have contributed equally to the work.
Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity
Article first published online: 11 OCT 2012
© 2012 The Authors Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 11, Issue 6, pages 1094–1101, December 2012
How to Cite
Zhao, L., Yang, F., Xu, K., Cao, H., Zheng, G.-Y., Zhang, Y., Li, J., Cui, H., Chen, X., Zhu, Z., He, H., Mo, X., Kennedy, B. K., Suh, Y., Zeng, Y. and Tian, X.-L. (2012), Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging Cell, 11: 1094–1101. doi: 10.1111/acel.12011
- Issue published online: 15 NOV 2012
- Article first published online: 11 OCT 2012
- Accepted manuscript online: 30 SEP 2012 03:45AM EST
- Manuscript Accepted: 14 SEP 2012
- National Basic Research Program of the Chinese Ministry of Science and Technology. Grant Number: 2007CB512100
- Key Program from the National Natural Science Foundation of China NSFC. Grant Numbers: 30730047, 70533010
- NIA/NIH. Grant Number: AG023627
Data S1 Sampling and genotyping.
Fig. S1 Protocol diagram for the inclusion of the participants.
Fig. S2 Signaling pathway of βAR/AC/ERK.
Fig. S3 Genotypic effects of SNPs rs1042718 and rs1042719 on BMI, systolic blood pressure and diastolic blood pressure in the oldest-old and young subjects.
Table S1 Characteristics of 96 centenarians and 96 young individuals from population 1.
Table S2 Primers list for genotyping.
Table S3 Allelic association of ADCY5, ADCY6, MAPK1, ADRB1 and ADRB2 with longevity in 96 centenarians and 96 young individuals from population 1.
Table S4 Allelic association of ADRB2 with longevity in females.
Table S5 Interaction of ADRB2 with gender in combined population.
Table S6 Enrichment of MAF with increased deathage.
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