Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity
Version of Record online: 17 OCT 2012
© 2012 The Authors Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 11, Issue 6, pages 1110–1120, December 2012
How to Cite
Yan, L., Park, J. Y., Dillinger, J.-G., De Lorenzo, M. S., Yuan, C., Lai, L., Wang, C., Ho, D., Tian, B., Stanley, W. C., Auwerx, J., Vatner, D. E. and Vatner, S. F. (2012), Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity. Aging Cell, 11: 1110–1120. doi: 10.1111/acel.12013
- Issue online: 15 NOV 2012
- Version of Record online: 17 OCT 2012
- Accepted manuscript online: 30 SEP 2012 03:46AM EST
- Manuscript Accepted: 16 SEP 2012
- National Institutes of Health grants. Grant Numbers: 5P01AG027211, 5R21HL097264, 1R01HL102472, 5R01HL033107, 5T32HL069752, 5R01HL095888, 5P01HL069020, 5R01HL091781, R01HL106511, R01HL093481, DK059820
- École Polytechnique Fédérale de Lausanne
- Swiss National Science Foundation
- Velux Foundation
- EU ideas program. Grant Number: ERC-2008-AdG-23118
Fig. S1 AC5 expression in mouse and human tissue expression panel derived from public database.
Fig. S2 Change of body weight and organ weight change after CR.
Fig. S3 Genes shared by AC5 KO and CR in liver.
Fig. S4 Comparison of control diet vs. ad lib diet on metabolism.
Fig. S5 Comparison of control diet vs. ad lib diet (n = 6/group) on the selective genes of olfactory receptors (Olfrs) and Sirt1 which were commonly shared by AC5 and CR (Fig. 5).
Fig. S6 Common gene pathways shared by different organs in 14 month old AC5 KO and CR.
Table S1 Similarities in gene ontology (GO) changes between AC5 KO and CR.
Table S2 Shared gene expression in different tissues of AC5 KO and CR.
Table S3 Upregulated and downregulated genes in both CR and AC5 KO that frequently contained binding sites for the following transcription factors.
Table S4 Significant TFBS.
Table S5 Primer sequences for qPCR.
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