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acel12025-sup-0001-FigureS1.tifimage/tif2849KFigure S1. Validation of WT aging – PLS model by permuting randomly the Age data with respect to the X data set. These re-estimations of the model evaluate the probability to obtain a good fit with random response data. R2 parameter (green triangles) estimates how well the model fits the data, and Q2 parameter (blue squares) provides an estimate of how well the model predicts the age data. Permutation of age data reduces considerably Q2, being negative or nonpredictive for most of the re-estimated models.

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