acel12027-sup-0001-FigureS1.pdfapplication/PDF173KFigure S1. Longevity and stress resistance of flies with reduced IPC expression of the mth paralogue, mth2.
acel12027-sup-0002-FigureS2.pdfapplication/PDF182KFigure S2. Longevity and stress resistance of mushroom body-specific overexpression of mth.
acel12027-sup-0003-FigureS3.pdfapplication/PDF167KFigure S3. Longevity and stress resistance of mth618 strain used to visualize insulin release in flies with IPC-specific mth overexpression.
acel12027-sup-0004-FigureS4.pdfapplication/PDF89KFigure S4. To rule out the possibility that overexpression of mth in the IPCs was simply killing those cells, we performed RT-PCR of brain specific Dilp2, 3 and 5 in old (40 days) flies.
acel12027-sup-0005-FigureS5.pdfapplication/PDF32KFigure S5. Similar to the long-lived lines reported herein, we note that in the original mth01 mutants described in (1), we also find enhanced dFOXO nuclear localization in the abdominal fatbody.
acel12027-sup-0006-FigureS6.pdfapplication/PDF150KFigure S6. As expected from long-lived flies with activated FOXO, CuZn- and MN-SOD activity is enhanced throughout life in both mth-overexpressing lines relative to controls.
acel12027-sup-0007-FigureS7.pdfapplication/PDF93KFigure S7. Loss of function Foxo21 mutants also reverts to control levels the longevity effect of IPC-specific mth overexpression in males as well as females.
acel12027-sup-0008-FigureS8.pdfapplication/PDF172KFigure S8. Effect of JNK manipulation on long-lived fly lines.
acel12027-sup-0009-FigureS9.pdfapplication/PDF15KFigure S9. Demonstration that human anti-FOXO antibody recognizes fly FOXO.
acel12027-sup-0010-TableS1.pdfapplication/PDF96KTable S1. Longevity summary of all fly lines used in this paper.

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