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Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging

  1. Joe R. Delaney1,2,
  2. Umema Ahmed1,
  3. Annie Chou1,
  4. Sylvia Sim1,
  5. Daniel Carr1,
  6. Christopher J. Murakami1,
  7. Jennifer Schleit1,
  8. George L. Sutphin1,2,
  9. Elroy H. An1,
  10. Anthony Castanza1,
  11. Marissa Fletcher1,
  12. Sean Higgins1,
  13. Monika Jelic1,
  14. Shannon Klum1,
  15. Brian Muller1,
  16. Zhao J. Peng1,
  17. Dilreet Rai1,
  18. Vanessa Ros1,
  19. Minnie Singh1,
  20. Helen V. Wende1,
  21. Brian K. Kennedy3,4,
  22. Matt Kaeberlein1,4,*

Article first published online: 25 DEC 2012

DOI: 10.1111/acel.12032

Issue

Aging Cell

Aging Cell

Volume 12, Issue 1, pages 156–166, February 2013

Additional Information

How to Cite

Delaney, J. R., Ahmed, U., Chou, A., Sim, S., Carr, D., Murakami, C. J., Schleit, J., Sutphin, G. L., An, E. H., Castanza, A., Fletcher, M., Higgins, S., Jelic, M., Klum, S., Muller, B., Peng, Z. J., Rai, D., Ros, V., Singh, M., Wende, H. V., Kennedy, B. K. and Kaeberlein, M. (2013), Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell, 12: 156–166. doi: 10.1111/acel.12032

Author Information

  1. 1

    Department of Pathology, University of Washington, Seattle, WA, USA

  2. 2

    Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA

  3. 3

    Buck Institute for Age Research, Novato, CA, USA

  4. 4

    Guangdong Medical College, Institute of Aging Research, Dongguan, China

* Correspondence
Matt Kaeberlein, Department of Pathology, University of Washington, Box 357470, Seattle, WA 98195-7470, USA. Tel.: +(206) 543 4849; fax: +(206) 543 3644; e-mail: kaeber@uw.edu

Publication History

  1. Issue published online: 17 JAN 2013
  2. Article first published online: 25 DEC 2012
  3. Accepted manuscript online: 20 NOV 2012 09:41AM EST
  4. Manuscript Accepted: 6 NOV 2012

Funded by

  • NIH. Grant Number: R01AG039390
  • NIH. Grant Numbers: T32AG000057, T32ES007032
  • Ellison Medical Foundation

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