Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging
Version of Record online: 25 DEC 2012
© 2012 The Authors Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 12, Issue 1, pages 156–166, February 2013
How to Cite
Delaney, J. R., Ahmed, U., Chou, A., Sim, S., Carr, D., Murakami, C. J., Schleit, J., Sutphin, G. L., An, E. H., Castanza, A., Fletcher, M., Higgins, S., Jelic, M., Klum, S., Muller, B., Peng, Z. J., Rai, D., Ros, V., Singh, M., Wende, H. V., Kennedy, B. K. and Kaeberlein, M. (2013), Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging. Aging Cell, 12: 156–166. doi: 10.1111/acel.12032
- Issue online: 17 JAN 2013
- Version of Record online: 25 DEC 2012
- Accepted manuscript online: 20 NOV 2012 09:41AM EST
- Manuscript Accepted: 6 NOV 2012
- NIH. Grant Number: R01AG039390
- NIH. Grant Numbers: T32AG000057, T32ES007032
- Ellison Medical Foundation
Fig. S1 Survival of long-lived strains following transient heat shock.
Fig. S2 Replicative lifespan curves of control strains sensitive to the tested stresses.
Fig. S3 Growth curves and lifespan curves of respiratory dead or deficient strains.
Fig. S4 Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves.
Fig. S5 Cold incubation similarly impairs afg3∆ cell growth and longevity relative to rpl20b∆ cells.
Fig. S6 WT and afg3∆ cells do not perish after 24 h in YPD medium.
Table S1 Summary of long-lived mutants' resistance profile: Tunicamycin.
Table S2 Summary of long-lived mutants' resistance profile: Paraquat.
Table S3 Summary of long-lived mutants' resistance profile: Heat shock.
Table S4 Summary of long-lived mutants' resistance profile: MMS.
Table S5 Strain list.
Table S6 Lifespan statistics.
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