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Data S1. Methods.

Fig. S1. Stable and inducible p21 depletion in senescent fibroblasts.

Fig. S2. Characterization of senescent BJ fibroblasts.

Fig. S3. Characterization of OIS fibroblasts.

Fig. S4. hTERT expression in transduced C3PV fibroblasts.

Fig. S5. H2AX phosphorylation in RS and OIS cells.

Fig. S6. Expression of DDR markers in quiescent fibroblasts.

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