SEARCH

SEARCH BY CITATION

References

  • Abecasis GR, Cherny SS, Cookson WO, Cardon LR (2002) Merlin–rapid analysis of dense genetic maps using sparse gene flow trees. Nat. Genet. 30, 97101.
  • Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D, Bergman A (2010) Genetic studies reveal the role of the endocrine and metabolic systems in aging. J. Clin. Endocrinol. Metab. 95, 44934500.
  • Bathum L, Christiansen L, Tan Q, Vaupel J, Jeune B, Christensen K (2005) No evidence for an association between extreme longevity and Microsomal Transfer Protein polymorphisms in a longitudinal study of 1651 nonagenarians. Eur. J. Hum. Genet. 13, 11541158.
  • Beekman M, Blauw GJ, Houwing-Duistermaat JJ, Brandt BW, Westendorp RG, Slagboom PE (2006) Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. J. Gerontol. A Biol. Sci. Med. Sci. 61, 355362.
  • Beekman M, Nederstigt C, Suchiman HE, Kremer D, Van der Breggen R, Lakenberg N, Alemayehu WG, De Craen AJ, Westendorp RG, Boomsma DI, de Geus EJ, Houwing-Duistermaat JJ, Heijmans BT, Slagboom PE (2010) Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. Proc. Natl Acad. Sci. USA 107, 1804618049.
  • Bekris LM, Lutz F, Yu CE (2012) Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE. J. Hum. Genet. 57, 1825.
  • Boyden SE, Kunkel LM (2010) High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. PLoS ONE 5, e12432.
  • Burdick JT, Chen WM, Abecasis GR, Cheung VG (2006) In silico method for inferring genotypes in pedigrees. Nat. Genet. 38, 10021004.
  • Callegaro A, van Houwelingen HC, Houwing-Duistermaat JJ (2009) Score test for age at onset genetic linkage analysis in selected sibling pairs. Stat. Med. 28, 19131926.
  • Chung WH, Dao RL, Chen LK, Hung SI (2010) The role of genetic variants in human longevity. Ageing Res. Rev. 9(Suppl 1), S67S78.
  • Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, Van der Breggen R, Suchiman HED, Lakenberg N, Van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, De CA, Rivadeneira F, De Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE (2011) Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10, 686698.
  • Edwards DR, Gilbert JR, Jiang L, Gallins PJ, Caywood L, Creason M, Fuzzell D, Knebusch C, Jackson CE, Pericak-Vance MA, Haines JL, Scott WK (2011) Successful aging shows linkage to chromosomes 6, 7, and 14 in the Amish. Ann. Hum. Genet. 75, 516528.
  • Franceschi C, Bezrukov V, Blanche H, Bolund L, Christensen K, De BG, Deiana L, Gonos E, Hervonen A, Yang H, Jeune B, Kirkwood TB, Kristensen P, Leon A, Pelicci PG, Peltonen L, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Slagboom PE, Spazzafumo L, Stazi MA, Toussaint O, Vaupel JW (2007) Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging). Ann. N. Y. Acad. Sci. 1100, 2145.
  • Geesaman BJ, Benson E, Brewster SJ, Kunkel LM, Blanche H, Thomas G, Perls TT, Daly MJ, Puca AA (2003) Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan. Proc. Natl Acad. Sci. USA 100, 1411514120.
  • Gudmundsson H, Gudbjartsson DF, Frigge M, Gulcher JR, Stefansson K (2000) Inheritance of human longevity in Iceland. Eur. J. Hum. Genet. 8, 743749.
  • Hjelmborg JV, Iachine I, Skytthe A, Vaupel JW, McGue M, Koskenvuo M, Kaprio J, Pedersen NL, Christensen K (2006) Genetic influence on human lifespan and longevity. Hum. Genet. 119, 312321.
  • Houwing-Duistermaat JJ, Callegaro A, Beekman M, Westendorp RG, Slagboom PE, van Houwelingen JC (2009) Weighted statistics for aggregation and linkage analysis of human longevity in selected families: the Leiden Longevity Study. Stat. Med. 28, 140151.
  • Jacobsen R, Martinussen T, Christiansen L, Jeune B, Andersen-Ranberg K, Vaupel JW, Christensen K (2010) Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes: two nationwide cohort studies. Aging Cell 9, 10041009.
  • Kruglyak L, Lander ES (1996) Limits on fine mapping of complex traits. Am. J. Hum. Genet. 58, 10921093.
  • Li M, Boehnke M, Abecasis GR (2005) Joint modeling of linkage and association: identifying SNPs responsible for a linkage signal. Am. J. Hum. Genet. 76, 934949.
  • Nebel A, Croucher PJ, Stiegeler R, Nikolaus S, Krawczak M, Schreiber S (2005) No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. Proc. Natl Acad. Sci. USA 102, 79067909.
  • Nebel A, Kleindorp R, Caliebe A, Nothnagel M, Blanche H, Junge O, Wittig M, Ellinghaus D, Flachsbart F, Wichmann HE, Meitinger T, Nikolaus S, Franke A, Krawczak M, Lathrop M, Schreiber S (2011) A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. Mech. Ageing Dev. 132, 324330.
  • Newman AB, Walter S, Lunetta KL, Garcia ME, Slagboom PE, Christensen K, Arnold AM, Aspelund T, Aulchenko YS, Benjamin EJ, Christiansen L, D'Agostino RB Sr, Fitzpatrick AL, Franceschini N, Glazer NL, Gudnason V, Hofman A, Kaplan R, Karasik D, Kelly-Hayes M, Kiel DP, Launer LJ, Marciante KD, Massaro JM, Miljkovic I, Nalls MA, Hernandez D, Psaty BM, Rivadeneira F, Rotter J, Seshadri S, Smith AV, Taylor KD, Tiemeier H, Uh HW, Uitterlinden AG, Vaupel JW, Walston J, Westendorp RG, Harris TB, Lumley T, van Duijn CM, Murabito JM (2010) A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. J. Gerontol. A Biol. Sci. Med. Sci. 65, 478487.
  • Paternoster L, Evans DM, Nohr EA, Holst C, Gaborieau V, Brennan P, Gjesing AP, Grarup N, Witte DR, Jorgensen T, Linneberg A, Lauritzen T, Sandbaek A, Hansen T, Pedersen O, Elliott KS, Kemp JP, St PB, McMahon G, Zelenika D, Hager J, Lathrop M, Timpson NJ, Smith GD, Sorensen TI (2011) Genome-wide population-based association study of extremely overweight young adults–the GOYA study. PLoS ONE 6, e24303.
  • Perls T, Shea-Drinkwater M, Bowen-Flynn J, Ridge SB, Kang S, Joyce E, Daly M, Brewster SJ, Kunkel L, Puca AA (2000) Exceptional familial clustering for extreme longevity in humans. J. Am. Geriatr. Soc. 48, 14831485.
  • Perls TT, Wilmoth J, Levenson R, Drinkwater M, Cohen M, Bogan H, Joyce E, Brewster S, Kunkel L, Puca A (2002) Life-long sustained mortality advantage of siblings of centenarians. Proc. Natl Acad. Sci. USA 99, 84428447.
  • Perola M, Sammalisto S, Hiekkalinna T, Martin NG, Visscher PM, Montgomery GW, Benyamin B, Harris JR, Boomsma D, Willemsen G, Hottenga JJ, Christensen K, Kyvik KO, Sorensen TI, Pedersen NL, Magnusson PK, Spector TD, Widen E, Silventoinen K, Kaprio J, Palotie A, Peltonen L (2007) Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet. 3, e97.
  • Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904909.
  • Puca AA, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T (2001) A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc. Natl Acad. Sci. USA 98, 1050510508.
  • Reed T, Dick DM, Uniacke SK, Foroud T, Nichols WC (2004) Genome-wide scan for a healthy aging phenotype provides support for a locus near D4S1564 promoting healthy aging. J. Gerontol. A Biol. Sci. Med. Sci. 59, 227232.
  • Rozing MP, Westendorp RG, De Craen AJ, Frolich M, de Goeij MC, Heijmans BT, Beekman M, Wijsman CA, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D (2010) Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study. J. Am. Geriatr. Soc. 58, 564569.
  • Schachter F, Cohen D, Kirkwood T (1993) Prospects for the genetics of human longevity. Hum. Genet. 91, 519526.
  • Schachter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D (1994) Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6, 2932.
  • Schoenmaker M, De Craen AJ, de Meijer PH, Beekman M, Blauw GJ, Slagboom PE, Westendorp RG (2006) Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur. J. Hum. Genet. 14, 7984.
  • Skytthe A, Pedersen NL, Kaprio J, Stazi MA, Hjelmborg JV, Iachine I, Vaupel JW, Christensen K (2003) Longevity studies in GenomEUtwin. Twin Res. 6, 448454.
  • Skytthe A, Valensin S, Jeune B, Cevenini E, Balard F, Beekman M, Bezrukov V, Blanche H, Bolund L, Broczek K, Carru C, Christensen K, Christiansen L, Collerton JC, Cotichini R, De Craen AJ, Dato S, Davies K, De BG, Deiana L, Flachsbart F, Gampe J, Gilbault C, Gonos ES, Haimes E, Hervonen A, Hurme MA, Janiszewska D, Jylha M, Kirkwood TB, Kristensen P, Laiho P, Leon A, Marchisio A, Masciulli R, Nebel A, Passarino G, Pelicci G, Peltonen L, Perola M, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Scurti M, Sevini F, Sikora E, Skouteri A, Slagboom PE, Spazzafumo L, Stazi MA, Toccaceli V, Toussaint O, Tornwall O, Vaupel JW, Voutetakis K, Franceschi C (2011) Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project. Exp. Gerontol. 46, 934945.
  • Slagboom PE, Beekman M, Passtoors WM, Deelen J, Vaarhorst AA, Boer JM, van den Akker EB, van Heemst D, De Craen AJ, Maier AB, Rozing M, Mooijaart SP, Heijmans BT, Westendorp RG (2011) Genomics of human longevity. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 3542.
  • Tan Q, Zhao JH, Iachine I, Hjelmborg J, Vach W, Vaupel JW, Christensen K, Kruse TA (2004) Power of non-parametric linkage analysis in mapping genes contributing to human longevity in long-lived sib-pairs. Genet. Epidemiol. 26, 245253.
  • Terry DF, Wilcox M, McCormick MA, Lawler E, Perls TT (2003) Cardiovascular advantages among the offspring of centenarians. J. Gerontol. A Biol. Sci. Med. Sci. 58, M425M431.
  • Uh HW, Deelen J, Beekman M, Helmer Q, Rivadeneira F, Hottenga JJ, Boomsma DI, Hofman A, Uitterlinden AG, Slagboom PE, Bohringer S, Houwing-Duistermaat JJ (2011) How to deal with the early GWAS data when imputing and combining different arrays is necessary. Eur. J. Hum. Genet. 20, 572576.
  • Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, Kumari M, Lunetta KL, Milaneschi Y, Tanaka T, Tranah GJ, Volker U, Yu L, Arnold A, Benjamin EJ, Biffar R, Buchman AS, Boerwinkle E, Couper D, De Jager PL, Evans DA, Harris TB, Hoffmann W, Hofman A, Karasik D, Kiel DP, Kocher T, Kuningas M, Launer LJ, Lohman KK, Lutsey PL, Mackenbach J, Marciante K, Psaty BM, Reiman EM, Rotter JI, Seshadri S, Shardell MD, Smith AV, van Duijn CM, Walston J, Zillikens MC, Bandinelli S, Baumeister SE, Bennett DA, Ferrucci L, Gudnason V, Kivimaki M, Liu Y, Murabito JM, Newman AB, Tiemeier H, Franceschini N (2011) A genome-wide association study of aging. Neurobiol. Aging 32, 21092128.
  • Westendorp RG, van Heemst D, Rozing MP, Frolich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, De Craen AJ, Slagboom PE (2009) Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: the Leiden longevity study. J. Am. Geriatr. Soc. 57, 16341637.