SEARCH

SEARCH BY CITATION

Keywords:

  • biological aging;
  • mRNA expression;
  • cell senescence;
  • predictive model

Summary

We have previously described a statistical model capable of distinguishing young (age <65 years) from old (age ≥75 years) individuals. Here we studied the performance of a modified model in three populations and determined whether individuals predicted to be biologically younger than their chronological age had biochemical and functional measures consistent with a younger biological age. Those with ‘younger’ gene expression patterns demonstrated higher muscle strength and serum albumin, and lower interleukin-6 and blood urea concentrations relative to ‘biologically older’ individuals (odds ratios 2.09, 1.64, 0.74, 0.74; P = 2.4 × 10−2, 3.5 × 10−4, 1.8 × 10−2, 1.5 × 10−2, respectively). We conclude that our expression signature of age is robust across three populations and may have utility for estimation of biological age.