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Data S1 Supplemental experimental procedures.

Fig S1 Staining of early passage and senescent cells for senescence-associated beta galactosidase activity (SA-β-Gal).

Fig S2 FAIRE-enriched genes are expressed at higher levels than FAIRE-non-enriched genes.

Fig S3 Genome-wide FAIRE enrichment of regions representing active promoters and strong enhancers in early passage and senescent cells.

Fig S4 The global FAIRE signal pattern becomes more homogeneous in senescent cells.

Fig S5 Growing and quiescent cells have very similar FAIRE profiles.

Fig S6 Relative abundance of Alu and SVA repetitive element subfamilies.

Fig S7 Relative abundance of L1 repetitive element subfamilies.

Fig S8 Relative abundance of human-specific L1H and primate-specific L1PA subfamilies of L1 repetitive elements.

Fig S9 Relative abundance of satellite repeat subfamilies.

Fig S10 qPCR quantification of FAIRE enrichment of Alu elements in senescent cells.

Fig S11 qPCR quantification of FAIRE enrichment of L1 elements in senescent cells.

Fig S12 qPCR quantification of FAIRE enrichment of satellite repeats in senescent cells.

Fig S13 qRT-PCR quantification of RNA expressed from Alu elements in senescent cells.

Fig S14 qRT-PCR quantification of RNA expressed from L1 elements in senescent cells.

Fig S15 qRT-PCR quantification of RNA expressed from hSATII elements in senescent cells.

Table S1 List of PCR primers.

Table S2 Alignment statistics of Illumina sequencing data.

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