acel12049-sup-0001-FigS1.pdfapplication/PDF12KFig. S1 Food intake was measured and used to calculate calories intake. Calories intake normalized for grams of body weight was scored daily at the beginning (weeks 1 and 2, A) and at the end of the dietary treatment (weeks 17–18, B) and was expressed as percentage calculated for the first week (days 1–7, PR diet) or the second week (days 8–14, refeeding with normal diet) of diet cycle compared with control diets values scored during the same periods (*P < 0.05, **P < 0.01, ***P < 0.001).
acel12049-sup-0002-FigS2.pdfapplication/PDF9KFig. S2 (A) Shown is SAB (spontaneous alternation behavior), obtained testing the mice with Y-maze after 12 weeks of PRC regimen. 3xTg-AD groups performed worse than WT control group (*P < 0.05, 13–14 mice per group). (B) Shown is the time spent in open arms scored testing the mice with EPM at 8–9 months of age, before any dietary treatment. We did not detect significant difference in the scored parameter (13–14 mice per group).
acel12049-sup-0003-FigS3.pdfapplication/PDF10KFig. S3 After 18 weeks of diet intervention, the mice were tested on Y-maze and NOR tests. (A) Shown is the number of arm entries scored during the Y-maze task. We did not detect significant difference among WT and 3xTg-AD groups (13–14 mice per group). (B) On trial 1 of NOR test, the rodents were allowed to explore a box containing two identical objects (object A and object B) and the time spent exploring them was recorded. No significant difference was found in the time the animals dedicated to explore the different objects (t-test: time object A vs. time object B, 12–14 mice per group).
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