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acel12060-sup-0001-FigS1.jpgimage/jpg264KFig. S1 p66 is required for oxidative stress-induced senescence and apoptosis.
acel12060-sup-0002-FigS2.jpgimage/jpg150KFig. S2 p53 transcriptional-response to oxidative stress in MEFs and thymus depends on p66 expression and involves genes that suppress the G2/M transition or mitosis.
acel12060-sup-0003-FigS3.jpgimage/jpg162KFig. S3 p53-p66 dependent transcriptional response at several sources of free radicals.
acel12060-sup-0004-FigS4.jpgimage/jpg178KFig. S4 p53/p66 transcriptional-response in regenerating hepatocytes and during involution of the thymus.
acel12060-sup-0005-FigS5.jpgimage/jpg92KFig S5 Binding of p53 to the NF-Y sites of the CyclinB2 promoter by chromatin immunoprecipitation (ChIP) in WT and p66−/− MEFs.
acel12060-sup-0006-FigS6.jpgimage/jpg144KFig. S6 Densitometry analysis.
acel12060-sup-0007-FigS7.jpgimage/jpg148KFig. S7 p66 deletion rescues senescence of p44Tg MEFs.
acel12060-sup-0008-FigS8.jpgimage/jpg129KFig. S8 Densitometry analysis.
acel12060-sup-0009-FigS9.jpgimage/jpg229KFig. S9 Representative images of thymus from 4 and 9 month-old WT, p44Tg and p44Tg-p66−/− animals.
acel12060-sup-0010-FigS10.jpgimage/jpg182KFig. S10 Effects of p66 on the aging-phenotypes of p44Tg mice.
acel12060-sup-0011-FigS11.jpgimage/jpg215KFig. S11 More effects of p66 on the aging phenotypes of p44Tg mice.
acel12060-sup-0012-DATASET1.xlsapplication/msexcel698KDataset S1 Gene expression changes in response to H2O2 in WT, p53−/− and p66Shc−/− MEFs MEFs.
acel12060-sup-0013-DATASET2.xlsxapplication/msexcel2304KDataset S2 Gene expression changes in tissues from 2-month old WT, p66−/− p53−/− and p53/p66dko mice.
acel12060-sup-0014-DATASET3.xlsxapplication/msexcel964KDataset S3 Gene expression changes in response to Doxorubicin in WT and p66−/−MEFs.
acel12060-sup-0015-DATASET4.xlsapplication/msexcel107KDataset S4 p53/p66-dependent gene regulations involved in cell-cycle control.
acel12060-sup-0016-TableS1-S8.docWord document15915K

Table S1 Functional enrichment of p53/p66-regulated genes.

Table S2 Raw data for expression analysis on main Figure 2A is presented.

Table S3. Raw data for expression analysis on main Figure 2C is presented.

Table S4. Raw data for expression analysis on main Figure 3B is presented.

Table S5 Raw data for expression analysis on main Figure 3E is presented.

Table S6 (a) Raw data for expression analysis on main Figure 4 is presented.

Table S7 (a)(supplementary on figure 5B). Raw data for expression analysis on main Figure 5B is presented.

Table S7 (b)(supplementary on figure 5E). Raw data for expression analysis on main Figure 5E is presented.

Table S8 Delayed aging in p44Tg and p44Tg-p66−/− mice.

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