Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
Article first published online: 27 MAR 2013
© 2013 The Authors Aging Cell © 2013 John Wiley & Sons Ltd and the Anatomical Society
Volume 12, Issue 3, pages 345–357, June 2013
How to Cite
Jackaman, C., Radley-Crabb, H. G., Soffe, Z., Shavlakadze, T., Grounds, M. D. and Nelson, D. J. (2013), Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice. Aging Cell, 12: 345–357. doi: 10.1111/acel.12062
- Issue published online: 13 MAY 2013
- Article first published online: 27 MAR 2013
- Accepted manuscript online: 26 FEB 2013 12:02PM EST
- Manuscript Accepted: 30 JAN 2013
- University and the Australian Government
Fig. S1 Suppressive MDSCs increase with age in lymph nodes.
Fig. S2 Macrophages from geriatric mice are capable of responding to M1 or M2 stimuli.
Fig. S3 Tumor supernatant induces M2 macrophages regardless of age.
Fig. S4 Macrophages from geriatric mice can induce CD4+ T cell Proliferation.
Fig. S5 Macrophages from young mice can induce proliferation of CD4+ T cells from geriatric mice.
Fig. S6 Macrophages from young mice can induce proliferation of CD8+ T cells from geriatric mice.
Fig. S7 IL-2/CD40 activated macrophages from young and geriatric mice secrete TNF-α, IFN-γ and IL-12.
Fig. S8 IL-2/CD40 activated macrophages from young and geriatric mice induce greater T cell divisions.
Fig. S9 IL-2/CD40 activated macrophages from young mice induce greater cell division of both young and geriatric T cells.
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