Both authors contributed equally to this work.
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
Article first published online: 23 APR 2013
© 2013 John Wiley & Sons Ltd and the Anatomical Society
Volume 12, Issue 3, pages 489–498, June 2013
How to Cite
Moiseeva, O., Deschênes-Simard, X., St-Germain, E., Igelmann, S., Huot, G., Cadar, A. E., Bourdeau, V., Pollak, M. N. and Ferbeyre, G. (2013), Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation. Aging Cell, 12: 489–498. doi: 10.1111/acel.12075
While this paper was on review, Struhl and colleagues published that metformin inhibits the expression of genes coding for inflammatory cytokines in breast cancer stem cells via inhibition of NF-κB (doi: 10.1073/pnas.1221055110), Hirsch HA, Iliopoulos D, Struhl K (2013). Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci U S A 110: 972–977.
- Issue published online: 13 MAY 2013
- Article first published online: 23 APR 2013
- Accepted manuscript online: 23 MAR 2013 09:19AM EST
- Manuscript Accepted: 9 MAR 2013
- Prostate Cancer Canada
|acel12075-sup-0001-FigureS1.eps||image/eps||1797K||Fig. S1 Biological functions analysis of microarrays data obtained from oncogenic ras expressing cells treated with metformin.|
|acel12075-sup-0002-FigureS2.eps||image/eps||3441K||Fig. S2 Metformin inhibits Toll-like receptors (TLRs) signaling to NF-κB.|
|acel12075-sup-0003-FigureS3.eps||image/eps||1260K||Fig. S3 Metformin inhibits genes regulated by NF-κB and C/EBPδ.|
|acel12075-sup-0004-DataS1.docx||Word document||38K||Data S1. Materials and methods.|
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