TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
Article first published online: 2 MAY 2013
© 2013 The Authors. Aging Cell published by John Wiley & Sons Ltd and the Anatomical Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 12, Issue 4, pages 563–573, August 2013
How to Cite
Rallis, C., Codlin, S. and Bähler, J. (2013), TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast. Aging Cell, 12: 563–573. doi: 10.1111/acel.12080
- Issue published online: 16 JUL 2013
- Article first published online: 2 MAY 2013
- Accepted manuscript online: 2 APR 2013 12:32AM EST
- Manuscript Accepted: 11 MAR 2013
- BBSRC Research Grant. Grant Number: BB/I012451/1
- Wellcome Trust Senior Investigator Award. Grant Number: 095598/Z/11/Z
|acel12080-sup-0001-FigS1.pdf||application/PDF||933K||Fig. S1 Survival assays of wild-type cells following drug treatment in YES and EMM media showing logarithmic scales of cell survival.|
|acel12080-sup-0002-FigS2.pdf||application/PDF||1907K||Fig.S2 Parallel measurements of cell growth and pH in media without (control) or with drugs as indicated, and CLS in buffered YES media with or without drugs as indicated|
|acel12080-sup-0003-FigS3.pdf||application/PDF||1236K||Fig. S3 Cell morphology and DNA content in caffeine and rapamycin-treated cells.|
|acel12080-sup-0004-FigS4.pdf||application/PDF||498K||Fig. S4 Growth analysis of cells in EMM media untreated (control) or treated with drugs as indicated.|
|acel12080-sup-0005-FigS5.pdf||application/PDF||1518K||Fig. S5 Correlation of cell viability with the concentrations of rapamycin and caffeine administered to growing cells.|
|acel12080-sup-0006-TableS1.xlsx||application/msexcel||36K||Table S1 List of genes regulated in cells treated with rapamycin and/or caffeine.|
|acel12080-sup-0007-TableS2.xlsx||application/msexcel||23K||Table S2 Summary of all CLS data in this study.|
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