These authors contributed equally to this research.
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
Article first published online: 5 JUN 2013
© 2013 John Wiley & Sons Ltd and the Anatomical Society
Volume 12, Issue 4, pages 645–651, August 2013
How to Cite
Mercken, E. M., Crosby, S. D., Lamming, D. W., JeBailey, L., Krzysik-Walker, S., Villareal, D. T., Capri, M., Franceschi, C., Zhang, Y., Becker, K., Sabatini, D. M., de Cabo, R. and Fontana, L. (2013), Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell, 12: 645–651. doi: 10.1111/acel.12088
- Issue published online: 16 JUL 2013
- Article first published online: 5 JUN 2013
- Accepted manuscript online: 20 APR 2013 01:58AM EST
- Manuscript Accepted: 12 APR 2013
- AFAR (American Federation for Aging Research). Grant Numbers: UL1 RR024992, P30DK056341, P30 CA91842, UL1RR024992
- National Institutes of Health (NIH)
- NIH Roadmap for Medical Research. Grant Numbers: UL1 RR024992, P30DK056341, P30 CA91842, UL1RR024992
- National Center for Research Resources. Grant Number: UL1 RR024992
- National Institute of Diabetes And Digestive And Kidney Diseases. Grant Number: P30DK056341
- National Institute on Aging-Intramural Research Program
- Longer Life Foundation
- Bakewell Foundation
- Calorie Restriction Society and the Scott and Annie Appleby Charitable Trust
- NCI Cancer Center. Grant Numbers: P30 CA91842, UL1RR024992
- National Center for Research Resources (NCRR)
Fig. S1 Kaplan–Meier survival analyses of ad libitum (AL) and 40% caloric restricted (CR) rats.
Table S1 Z-scores of the top 100 pathways significantly changed by either WD or CR.
Table S2 RT-qPCR/QuantiGene based assay validation of micro-array data.
Table S3 Z-scores of common pathways between humans and rats.
Table S4 Z-scores of 3 central pathways altered by CR between humans and rats.
Table S5 Primer sequences and probe set region used for quantitative PCR analysis or Quantigene based assays.
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