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Fig. S1 Kaplan–Meier survival analyses of ad libitum (AL) and 40% caloric restricted (CR) rats.

Table S1 Z-scores of the top 100 pathways significantly changed by either WD or CR.

Table S2 RT-qPCR/QuantiGene based assay validation of micro-array data.

Table S3 Z-scores of common pathways between humans and rats.

Table S4 Z-scores of 3 central pathways altered by CR between humans and rats.

Table S5 Primer sequences and probe set region used for quantitative PCR analysis or Quantigene based assays.

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