Expression of catalytically active matrix metalloproteinase-1 in dermal fibroblasts induces collagen fragmentation and functional alterations that resemble aged human skin
Article first published online: 15 MAY 2013
© 2013 John Wiley & Sons Ltd and the Anatomical Society
Volume 12, Issue 4, pages 661–671, August 2013
Total views since publication: 162
How to Cite
Xia, W., Hammerberg, C., Li, Y., He, T., Quan, T., Voorhees, J. J. and Fisher, G. J. (2013), Expression of catalytically active matrix metalloproteinase-1 in dermal fibroblasts induces collagen fragmentation and functional alterations that resemble aged human skin. Aging Cell, 12: 661–671. doi: 10.1111/acel.12089
- Issue published online: 16 JUL 2013
- Article first published online: 15 MAY 2013
- Accepted manuscript online: 20 APR 2013 01:58AM EST
- Manuscript Accepted: 11 APR 2013
- National Institutes of Health. Grant Numbers: RO1-AG025186-S1, RO1-AG025186 GF, RO1-AG031452 GF, RO1-AG019364 GF
Fig. S1 Diagram of human MMP-1 expression constructs.
Fig. S2 Time- and temperature dependence of MMP-1 V94G auto-activation.
Fig. S3 Expression of MMP-1 V94G in dermal fibroblasts degrades three-dimensional type I collagen lattices creating a fragmented extracellular matrix.
Fig. S4 siRNA-mediated MMP-1 knockdown.
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