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Fig. S1 Diagram of human MMP-1 expression constructs.

Fig. S2 Time- and temperature dependence of MMP-1 V94G auto-activation.

Fig. S3 Expression of MMP-1 V94G in dermal fibroblasts degrades three-dimensional type I collagen lattices creating a fragmented extracellular matrix.

Fig. S4 siRNA-mediated MMP-1 knockdown.

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