Expression of catalytically active matrix metalloproteinase-1 in dermal fibroblasts induces collagen fragmentation and functional alterations that resemble aged human skin
Version of Record online: 15 MAY 2013
© 2013 John Wiley & Sons Ltd and the Anatomical Society
Volume 12, Issue 4, pages 661–671, August 2013
How to Cite
Xia, W., Hammerberg, C., Li, Y., He, T., Quan, T., Voorhees, J. J. and Fisher, G. J. (2013), Expression of catalytically active matrix metalloproteinase-1 in dermal fibroblasts induces collagen fragmentation and functional alterations that resemble aged human skin. Aging Cell, 12: 661–671. doi: 10.1111/acel.12089
- Issue online: 16 JUL 2013
- Version of Record online: 15 MAY 2013
- Accepted manuscript online: 20 APR 2013 01:58AM EST
- Manuscript Accepted: 11 APR 2013
- National Institutes of Health. Grant Numbers: RO1-AG025186-S1, RO1-AG025186 GF, RO1-AG031452 GF, RO1-AG019364 GF
Fig. S1 Diagram of human MMP-1 expression constructs.
Fig. S2 Time- and temperature dependence of MMP-1 V94G auto-activation.
Fig. S3 Expression of MMP-1 V94G in dermal fibroblasts degrades three-dimensional type I collagen lattices creating a fragmented extracellular matrix.
Fig. S4 siRNA-mediated MMP-1 knockdown.
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