Fig. S1 Tel1 and the MRX complex act in the same pathway to modulate senescence.

Fig. S2 Rif2 acts upstream of the MRX complex to regulate replicative senescence.

Fig. S3 Rad50 and Rad52 contribute to senescence through pathway(s) that are distince from the MRX pathway

Fig. S4 Phenotypic consequences of a sae2-Δ null mutation in strains that lack telomerase or Sgs1.

Fig. S5 Rif1 contributes to replicative senescence transiently, and only in the absence of Rif2.

Table S1 Strains used in this study.

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