Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast
Article first published online: 28 JUN 2013
© 2013 John Wiley & Sons Ltd and the Anatomical Society
Volume 12, Issue 4, pages 719–727, August 2013
How to Cite
Ballew, B. J. and Lundblad, V. (2013), Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast. Aging Cell, 12: 719–727. doi: 10.1111/acel.12099
- Issue published online: 16 JUL 2013
- Article first published online: 28 JUN 2013
- Accepted manuscript online: 14 MAY 2013 08:18AM EST
- Manuscript Accepted: 7 MAY 2013
- National Institute of Health. Grant Number: R37 AG11728
- Cancer Center Core. Grant Number: P30 CA014195
Fig. S1 Tel1 and the MRX complex act in the same pathway to modulate senescence.
Fig. S2 Rif2 acts upstream of the MRX complex to regulate replicative senescence.
Fig. S3 Rad50 and Rad52 contribute to senescence through pathway(s) that are distince from the MRX pathway
Fig. S4 Phenotypic consequences of a sae2-Δ null mutation in strains that lack telomerase or Sgs1.
Fig. S5 Rif1 contributes to replicative senescence transiently, and only in the absence of Rif2.
Table S1 Strains used in this study.
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