Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice
Article first published online: 11 JUN 2013
© 2013 The Anatomical Society and John Wiley & Sons Ltd
Volume 12, Issue 5, pages 763–771, October 2013
How to Cite
Siegel, M. P., Kruse, S. E., Percival, J. M., Goh, J., White, C. C., Hopkins, H. C., Kavanagh, T. J., Szeto, H. H., Rabinovitch, P. S. and Marcinek, D. J. (2013), Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Aging Cell, 12: 763–771. doi: 10.1111/acel.12102
- Issue published online: 11 SEP 2013
- Article first published online: 11 JUN 2013
- Accepted manuscript online: 20 MAY 2013 09:16AM EST
- Manuscript Accepted: 10 MAY 2013
- Ellison Medical Foundation
- Nathan Shock Center of Excellence in the Basic Biology of Aging
Fig. S1 SS-31 is rapidly elevated in skeletal muscle and declines to 10% of its maximum value after 16 h.
Fig. S2 ETC complex protein expression was not different one hour after injection of 3 mg kg−1 SS-31 in old mice.
Fig. S3 Representative fully relaxed spectra from SS-31-treated and control old mice illustrate an increase in relative peak area of PCr to γATP.
Fig. S4 Daily SS-31 treatment did not affect voluntary running distance in old mice. Mean ± SEM. n = 6–7 per group.
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