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Fig. S1 Resident macrophages from aged mice are more susceptible to TM-induced apoptosis than young macrophages.

Fig. S2 Aged macrophages are more susceptible to 7-ketocholesterol and free cholesterol induced apoptosis than young macrophages.

Fig. S3 Aged macrophages exhibit lower p-IRE1α protein levels than young macrophages after different doses of TM treatment.

Fig. S4 The impact of aging on the PERK and ATF6 branches in macrophages before and after treatment with TM.

Fig. S5 IRE1α activation is enhanced in macrophages from XBP1-inducible knockout mice.

Fig. S6 Si-XBP1 does not impact CHOP levels in macrophages.

Fig. S7 IRE1α activation is enhanced in macrophages treated with si-XBP1, and reduced in macrophages treated with si-IRE1α.

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