Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages
Article first published online: 7 JUL 2013
© 2013 The Anatomical Society and John Wiley & Sons Ltd
Volume 12, Issue 5, pages 794–801, October 2013
Total views since publication: 405
How to Cite
Song, Y., Shen, H., Du, W. and Goldstein, D. R. (2013), Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages. Aging Cell, 12: 794–801. doi: 10.1111/acel.12105
- Issue published online: 11 SEP 2013
- Article first published online: 7 JUL 2013
- Accepted manuscript online: 28 MAY 2013 03:50AM EST
- Manuscript Accepted: 22 MAY 2013
- NIH. Grant Numbers: AG028082, AG033049
- Established Investigator Award. Grant Number: 0940006N
Fig. S1 Resident macrophages from aged mice are more susceptible to TM-induced apoptosis than young macrophages.
Fig. S2 Aged macrophages are more susceptible to 7-ketocholesterol and free cholesterol induced apoptosis than young macrophages.
Fig. S3 Aged macrophages exhibit lower p-IRE1α protein levels than young macrophages after different doses of TM treatment.
Fig. S4 The impact of aging on the PERK and ATF6 branches in macrophages before and after treatment with TM.
Fig. S5 IRE1α activation is enhanced in macrophages from XBP1-inducible knockout mice.
Fig. S6 Si-XBP1 does not impact CHOP levels in macrophages.
Fig. S7 IRE1α activation is enhanced in macrophages treated with si-XBP1, and reduced in macrophages treated with si-IRE1α.
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