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References S1 Additional method citations.

Fig. S1 Rapamycin affects on mTOR signaling pathways.

Fig. S2 Skeletal analysis.

Fig. S3 Voluntary wheel running.

Fig. S4 RNA-seq promoter motif analysis.

Fig. S5 Ingenuity pathway analysis of RAD-related genes.

Fig. S6 Western blot of RAD protein content in heart tissue.

Table S1 Behavioral time budget analysis.

Table S2 Echocardiography speckle-tracking strain and strain rate analysis.

Table S3 RNA-seq differential gene expression.

Table S4 Promoter motif analysis statistics.

Data S1 Experimental methods.

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