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Fig. S1 SAL-RNA levels in proliferating (untreated) and senescent (IR) WI-38 cells.

Fig. S2 SAL-RNA levels in proliferating (P, PDL 25) and pre-senescent (S, PDL 49) IMR-90 cells.

Fig. S3 SAL-RNAs differentially expressed in WI-38 fibroblasts (untreated versus IR) and in IMR-90 (proliferating versus late-passage).

Fig. S4 Northern blot analysis of the levels of lncRNAs SAL-RNA1 (XLOC_023166), SAL-RNA2 (XLOC_025931), SAL-RNA3 (XLOC_025918), as well as loading control 18S rRNA in P and S WI-38 cells.

Fig. S5 (A) Top, sequence of novel SAL-RNA XLOC_023166, preferentially expressed in proliferating WI-38 fibroblasts and genomic region containing XLOC_023166.

Table S1 Additional information on naturally occurring antisense transcripts (NA)-SAL-RNAs differentially expressed in P relative to S WI-38 fibroblasts, as identified by RNA-Seq analysis.

Table S2 Additional information on pseudogene-encoded (PE) lncRNAs differentially expressed in P relative to S WI-38 fibroblasts, as identified by RNA-Seq analysis.

Table S3 Additional information of other known lncRNAs differentially expressed in P relative to S WI-38 fibroblasts, as identified by RNA-Seq analysis.

Table S4 Additional details of novel lncRNAs expressed more highly in proliferating WI-38 fibroblasts, identified by RNA-Seq analysis.

Table S5 Additional details of novel lncRNAs expressed more highly in senescent WI-38 fibroblasts, identified by RNA-Seq analysis.

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