Analysing variation in Drosophila aging across independent experimental studies: a meta-analysis of survival data
Article first published online: 22 JUL 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 12, Issue 5, pages 917–922, October 2013
How to Cite
Ziehm, M., Piper, M. D. and Thornton, J. M. (2013), Analysing variation in Drosophila aging across independent experimental studies: a meta-analysis of survival data. Aging Cell, 12: 917–922. doi: 10.1111/acel.12123
- Issue published online: 11 SEP 2013
- Article first published online: 22 JUL 2013
- Accepted manuscript online: 24 JUN 2013 06:49AM EST
- Manuscript Accepted: 7 JUN 2013
- Royal Society and the BBSRC
- Wellcome Trust Strategic Award. Grant Number: 081394/B/06/Z
- Drosophila ;
- survival data
Survival records of longevity experiments are a key component in research on aging. However, surprisingly there have been very few cross-study analyses, besides comparisons of median lifespans or similar summary information. Here, we use a large set of full survival data from various studies to address questions in aging, which are beyond the scope of individual studies. We characterize survival differences between female and male flies of different genetic Drosophila strains, showing significant differences between strains. We further analyse the variation in survival of control cohorts recorded under highly similar conditions within different Drosophila strains. We found that overall transgenic constructs of the UAS/GAL4 expression system which should have no effect (e.g. a GAL4 construct alone) extend lifespan significantly in the w1118 strain. Using a large data set comprised of various studies, we found no evidence for larger lifespan extensions being associated with shorter lifespans of the control in Drosophila. This demonstrates that lifespan extending treatments are not purely rescuing weak backgrounds.