Véronique De Vaux and Catherine Pfefferli authors contributed equally to this work.
The Caenorhabditis elegans LET-418/Mi2 plays a conserved role in lifespan regulation
Version of Record online: 16 AUG 2013
© 2013 the Anatomical Society and John Wiley & Sons Ltd
Volume 12, Issue 6, pages 1012–1020, December 2013
How to Cite
De Vaux, V., Pfefferli, C., Passannante, M., Belhaj, K., von Essen, A., Sprecher, S. G., Müller, F. and Wicky, C. (2013), The Caenorhabditis elegans LET-418/Mi2 plays a conserved role in lifespan regulation. Aging Cell, 12: 1012–1020. doi: 10.1111/acel.12129
- Issue online: 21 NOV 2013
- Version of Record online: 16 AUG 2013
- Accepted manuscript online: 1 JUL 2013 10:03AM EST
- Manuscript Accepted: 18 JUN 2013
- SNF. Grant Numbers: 31003A_125577, PP00P3_123339
Fig. S1 The let-418::gfp transgenes, swEx661 and swEx662 are not expressed in the germ cells.
Fig. S2 The mRNA level of tcer-1 was quantified using qRT-PCR.
Fig. S3 Loss of let-418 does not result in altered DAF-16 subcellular localization or a change in the daf-16 mRNA levels.
Fig. S4 tbh-1, clec-87 and vit-3 are downregulated in let-418(lf) mutants.
Fig. S5 The efficiency of kri-1 RNA depletion was assessed using kri-1::gfp transgenic worms.
Table S1 Mutations in let-418 increase lifespan.
Table S2 Reproductive status of let-418 alleles.
Table S3 let-418 genetic interactions with other mutations influencing ageing.
Table S4 Mutations in let-418 enhance oxidative stress resistance.
Table S5 Mutations in let-418 enhance thermic stress resistance.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.