Endoplasmic reticulum stress activates telomerase
Article first published online: 22 OCT 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 1, pages 197–200, February 2014
How to Cite
Zhou, J., Mao, B., Zhou, Q., Ding, D., Wang, M., Guo, P., Gao, Y., Shay, J. W., Yuan, Z. and Cong, Y.-S. (2014), Endoplasmic reticulum stress activates telomerase. Aging Cell, 13: 197–200. doi: 10.1111/acel.12161
- Issue published online: 16 JAN 2014
- Article first published online: 22 OCT 2013
- Accepted manuscript online: 9 OCT 2013 10:35AM EST
- Manuscript Accepted: 12 SEP 2013
- National Basic Research Program of China. Grant Number: 2012CB911203
- National Natural Science Foundation of China. Grant Numbers: 31371398, 31071200, 31171320, 31201038
- ER stress;
Telomerase contributes to cell proliferation and survival through both telomere-dependent and telomere-independent mechanisms. In this report, we discovered that endoplasmic reticulum (ER) stress transiently activates the catalytic components of telomerase (TERT) expression in human cancer cell lines and murine primary neural cells. Importantly, we show that depletion of hTERT sensitizes cells to undergo apoptosis under ER stress, whereas increased hTERT expression reduces ER stress-induced cell death independent of catalytically active enzyme or DNA damage signaling. Our findings establish a functional link between ER stress and telomerase, both of which have important implications in the pathologies associated with aging and cancer.