A pharmacological network for lifespan extension in Caenorhabditis elegans
Article first published online: 13 NOV 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 2, pages 206–215, April 2014
How to Cite
Ye, X., Linton, J. M., Schork, N. J., Buck, L. B. and Petrascheck, M. (2014), A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell, 13: 206–215. doi: 10.1111/acel.12163
- Issue published online: 11 MAR 2014
- Article first published online: 13 NOV 2013
- Accepted manuscript online: 17 OCT 2013 10:41AM EST
- Manuscript Accepted: 3 SEP 2013
- Howard Hughes Medical Institute
- Ellison Medical Foundation
- National Institutes of Health. Grant Number: DP2 OD008398
- NIA Longevity Consortium. Grant Numbers: 2 U19 AG023122, 8UL1 TR000109
- NIH Office of Research Infrastructure Programs. Grant Number: P40 OD010440
Fig. S1 Lifespan-extending compounds can show structural similarity or have common substructures.
Fig. S2 Structures of lifespan-extending compounds and their effects on stress resistance.
Fig. S3 Dose response curves for lifespan-extending compounds.
Fig. S4 Effects of lifespan-extending compounds on bacterial growth.
Fig. S5 Parametric survival-time model based on the Gompertz equation.
Fig. S6 Density function f(t).
Fig. S7 Probability of detecting % increases in lifespan.
Table S1 Results of primary screen.
Table S2 Summary of C. elegans lifespan experiments with 57 hit compounds.
Table S3 Summary of stress resistance experiments in C. elegans.
Table S4 Screening data overview and total numbers.
Data S1 Generation of a parametric survival-time model.
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.