H3K4 demethylase activities repress proliferative and postmitotic aging
Article first published online: 19 NOV 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 2, pages 245–253, April 2014
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How to Cite
Alvares, S. M., Mayberry, G. A., Joyner, E. Y., Lakowski, B. and Ahmed, S. (2014), H3K4 demethylase activities repress proliferative and postmitotic aging. Aging Cell, 13: 245–253. doi: 10.1111/acel.12166
- Issue published online: 11 MAR 2014
- Article first published online: 19 NOV 2013
- Accepted manuscript online: 17 OCT 2013 10:41AM EST
- Manuscript Accepted: 23 SEP 2013
- National Institutes of Health, Training, Workforce Development
- Diversity division of the National Institute of General Medical Sciences (NIGMS). Grant Number: K12GM000678
- NIH . Grant Number: GM083048
- Caenorhabditis elegans ;
- cellular aging;
- histone demethylase;
- life span
Homeostasis of postmitotic and proliferating cells is maintained by pathways that repress stress. We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and promoted silencing of some daf-2 target genes. In addition, RBR-2 and SPR-5 were required for germ cell immortality at a high temperature. Transgenerational proliferative aging was enhanced for spr-5; rbr-2 double mutants, suggesting that these histone demethylases may function sequentially to promote germ cell immortality by targeting distinct H3K4 methyl marks. RBR-2 did not play a comparable role in the maintenance of quiescent germ cells in dauer larvae, implying that it represses stress that occurs as a consequence of germ cell proliferation, rather than stress that accumulates in nondividing cells. We propose that H3K4 demethylase activities promote the maintenance of chromatin states during stressful growth conditions, thereby repressing postmitotic aging of somatic cells as well as proliferative aging of germ cells.