H3K4 demethylase activities repress proliferative and postmitotic aging
Article first published online: 19 NOV 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 2, pages 245–253, April 2014
How to Cite
Alvares, S. M., Mayberry, G. A., Joyner, E. Y., Lakowski, B. and Ahmed, S. (2014), H3K4 demethylase activities repress proliferative and postmitotic aging. Aging Cell, 13: 245–253. doi: 10.1111/acel.12166
- Issue published online: 11 MAR 2014
- Article first published online: 19 NOV 2013
- Accepted manuscript online: 17 OCT 2013 10:41AM EST
- Manuscript Accepted: 23 SEP 2013
- National Institutes of Health, Training, Workforce Development
- Diversity division of the National Institute of General Medical Sciences (NIGMS). Grant Number: K12GM000678
- NIH . Grant Number: GM083048
|acel12166-sup-0001-FigS1.eps||image/eps||511K||Fig. S1 rbr-2(ok2544) affects longevity at higher temperatures.|
|acel12166-sup-0002-FigS2.eps||image/eps||568K||Fig. S2 The effects of rbr-2 on daf-2(e1368)-mediated longevity.|
|acel12166-sup-0003-FigS3.eps||image/eps||540K||Fig. S3 Mutations in H3K4 demethylases do not affect fertility for strains propagated at 20 °C.|
|acel12166-sup-0004-FigS4.eps||image/eps||3752K||Fig. S4 DAPI-stained oocytes with chromosome defects.|
|acel12166-sup-0005-DataS1.doc||Word document||39K||Data S1 Methods.|
Table S1 Smaller body size and vulval defects in rbr-2(tm1231) but not rbr-2(ok2544).
Table S2 Deficiencies for H3K4 demethylase activity decreases longevity in a daf-2(e1370) background.
Table S3 Dauer formation and L1 or L2 larval arrests of progeny from daf-2(e1370) and daf-2(e1370) H3K4 demethylase double mutants that were shifted from 15 °C to either 20 or 25 °C as L4 larvae.
Table S4 Dauer formation and L1 or L2 larval arrests of progeny from daf-2(e1370), H3K4 demethylase mutants that were shifted from 15 °C to either 20 or 25 °C as embryos.
Table S5 Quantification of H3K4me2 compared to total H3K4 levels.
Table S6 Quantification of H3K4me3 compared to total H3K4 levels.
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