These three authors contributed equally to this study.
Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
Article first published online: 19 NOV 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 2, pages 273–282, April 2014
How to Cite
Harrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., Nelson, J. F., Pletcher, S., Simpkins, J. W., Smith, D., Wilkinson, J. E. and Miller, R. A. (2014), Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell, 13: 273–282. doi: 10.1111/acel.12170
- Issue published online: 11 MAR 2014
- Article first published online: 19 NOV 2013
- Accepted manuscript online: 26 OCT 2013 06:22AM EST
- Manuscript Accepted: 10 OCT 2013
- NIA. Grant Numbers: AG022308, AG022303, AG022307
- Department of Veterans Affairs Office of Research and Development
Fig. S1 ACA treatment: Site-specific survival curves for UM-HET3 controls (A,B) and ACA-fed male (C) and female (D) mice.
Fig. S2 ACA, EST and MB treatment: weights for UM-HET3 controls and males (A–C) and females (D–F) at TJL (A,D), UM (B,E), and UT (C,F).
Fig. S3 EST treatment: Survival for UM-HET3 control females pooled across sites (A) and EST-treated females at TJL (B), UM (C), and UT (D).
Fig. S4 NDGA treatment: Interim survival for UM-HET3 controls and NDGA-treated males at TJL (A), UM (B), and UT (C), and UM-HET3 controls and NDGA-treated females at TJL (D), UM (E), and UT (F).
Fig. S5 NDGA levels in plasma of UM-HET3 controls and males treated with high (5000 ppm), middle (2500 ppm), or low dose (9800 ppm) of NDGA in the diet (A), and UM-HET3 controls and females treated with high dose of NDGA (B).
Fig. S6 NDGA treatment: Body weights for UM-HET3 controls and males treated with high, middle, and low dose of NDGA (A), and for UM-HET3 controls and females treated with high dose of NDGA (B).
Fig. S7 MB treatment: Survival curves for UM-HET3 controls and mice fed MB in the diet for males at TJL (A), UM (B), and UT (C), and for females at TJL (D), UM (E), and UT (F).
Table S1 ACA and EST treatment: Inferred causes of death in aging UM-HET3 controls and ACA- and EST-treated males and females
Table S2 Survival in UM-HET3 control and male mice that were treated with ACA, EST, and MB in the diet and that lived at least 600 days
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