Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy
Version of Record online: 4 DEC 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 2, pages 303–310, April 2014
How to Cite
Jasuja, R., Costello, J. C., Singh, R., Gupta, V., Spina, C. S., Toraldo, G., Jang, H., Li, H., Serra, C., Guo, W., Chauhan, P., Narula, N. S., Guarneri, T., Ergun, A., Travison, T. G., Collins, J. J. and Bhasin, S. (2014), Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy. Aging Cell, 13: 303–310. doi: 10.1111/acel.12174
- Issue online: 11 MAR 2014
- Version of Record online: 4 DEC 2013
- Manuscript Accepted: 21 OCT 2013
- NIA. Grant Number: 5R01AG037193
- Boston Claude D. Pepper Center. Grant Numbers: 5P30AG031679, SC1AG033407-01A1
Fig. S1 Comparison of pathway expression for the prostate on a subnetwork centered on the Gene Ontology (GO) term, ‘polyamine biosynthetic process.’
Fig. S2 Differential regulation of Odc1 mRNA expression in prostate tissues obtained from castrated mice after testosterone and Fst treatments.
Fig. S3 Recombinant Fst does not affect Odc1 protein expression in LnCaP cells.
Fig. S4 Odc1 expression is consistently upregulated by testosterone supplementation in castrated mice in vivo.
Fig. S5 Effect of castration and testosterone supplementation on prostate weights in mice.
|acel12174-sup-0002-TableS1.xlsx||application/msexcel||4941K||Table S1 Gene expression analysis for identifying androgen-sensitive and follistatin-sensitive genes in the prostate and levator ani, along with Gene Ontology (GO) term enrichment analysis for the associated sets of genes.|
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