Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver
Version of Record online: 5 DEC 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 2, pages 311–319, April 2014
How to Cite
Fok, W. C., Bokov, A., Gelfond, J., Yu, Z., Zhang, Y., Doderer, M., Chen, Y., Javors, M., Wood, W. H., Zhang, Y., Becker, K. G., Richardson, A. and Pérez, V. I. (2014), Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. Aging Cell, 13: 311–319. doi: 10.1111/acel.12175
- Issue online: 11 MAR 2014
- Version of Record online: 5 DEC 2013
- Accepted manuscript online: 5 DEC 2013 05:41AM EST
- Manuscript Accepted: 15 OCT 2013
- The San Antonio Nathan Shock Aging Center. Grant Number: 1p30-AG-13319
- National Institutes of Health (NIH). Grant Number: AG036613
- NIH T32 Training Grant. Grant Number: AG021890
- Ellison Medical Foundation
- Intramural Research Program of the NIH
- National Institute on Aging
|acel12175-sup-0001-DataS1.doc||Word document||40K||Data S1 Methods.|
Fig. S1 mTOR signaling pathways have similar decrease in all three groups.
Fig. S2 Rapamycin levels in livers of Rapa and Rapa + DR mice.
Fig. S3 qRT-PCR of genes in the livers of female mice fed multiple doses of rapamycin.
Table S1 Both linear discrimination predictor and quadratic discriminant analysis show differences between Rapa and DR.
Table S2 Percent change in the transcriptome analysis using various filtering criteria.
Table S3 Caloric and diet composition of LabDiet 5LG6-JL diet.
Table S4 Genes potentiated by the combined treatment of rapamycin and dietary restriction.
File S1 File (SF1- Dataset.xls) containing data for significantly changed gene list, IPA pathways, pathway comparisons, and metabolites.
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