These authors contributes equally to this work.
let-7-repressesed Shc translation delays replicative senescence
Version of Record online: 25 NOV 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 1, pages 185–192, February 2014
How to Cite
Xu, F., Pang, L., Cai, X., Liu, X., Yuan, S., Fan, X., Jiang, B., Zhang, X., Dou, Y., Gorospe, M. and Wang, W. (2014), let-7-repressesed Shc translation delays replicative senescence. Aging Cell, 13: 185–192. doi: 10.1111/acel.12176
- Issue online: 16 JAN 2014
- Version of Record online: 25 NOV 2013
- Accepted manuscript online: 26 OCT 2013 09:02AM EST
- Manuscript Accepted: 15 OCT 2013
- National Science Foundation of China. Grant Numbers: 8123008, 81070247, 30921062, 30973147
- Ministry of Education of People's Republic of China. Grant Number: B07001
- National Institute on Aging-IRP, National Institutes of Health
Fig. S1 Schematic representation depicting the coding region (CR) and mutants of Src family mRNA.
Fig. S2 let-7a specifically represses the expression of p66Shc.
Fig. S3 let-7a inhibits the loading of p66Shc onto the p bodies but promotes the presence of p66Shc in the polysome.
Fig. S4 Overexpression of p66Shc shortens the life span and accelerates the replicative senescence of HDFs.
Fig. S5 Overexpression of p52Shc does not influence replicative senescence and life span.
Fig. S6 Overexpression of p46Shc does not influence replicative senescence and life-span.
Fig. S7 Ectopic expression of p66Shc CR fragment rescues the effect of let-7a on repressing p66Shc expression and extending the cellular life span.
Data S1 Experimental procedures.
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