F. Sevini and N. Raule equally contributed to the study.
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific
Article first published online: 17 DEC 2013
© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 13, Issue 3, pages 401–407, June 2014
How to Cite
Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J. S., Bezrukov, V., Blanché, H., Hervonen, A., Christensen, K., Deiana, L., Gonos, E. S., Kirkwood, T. B. L., Kristensen, P., Leon, A., Pelicci, P. G., Poulain, M., Rea, I. M., Remacle, J., Robine, J. M., Schreiber, S., Sikora, E., Eline Slagboom, P., Spazzafumo, L., Antonietta Stazi, M., Toussaint, O., Vaupel, J. W., Rose, G., Majamaa, K., Perola, M., Johnson, T. E., Bolund, L., Yang, H., Passarino, G. and Franceschi, C. (2014), The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell, 13: 401–407. doi: 10.1111/acel.12186
- Issue published online: 23 MAY 2014
- Article first published online: 17 DEC 2013
- Manuscript Accepted: 14 NOV 2013
- Life Sciences, Genomics and Biotechnology for Health
- European Union's FP6. Grant Number: LSHM-CT-2004-503270
- European Union's Seventh Framework. Grant Numbers: FP7/2007-2011, 259679
|acel12186-sup-0001-FigS1.pdf||application/PDF||59K||Fig. S1 Scatterplot of the first two principal component scores based on the 229 SNPs (MAF > 0.01) identified in the 1291 mtDNA analyzed sequences.|
|acel12186-sup-0002-TabS1.pdf||application/PDF||27K||Table S1. a and b. Haplogroup distribution in males and females.|
|acel12186-sup-0003-TabS2.pdf||application/PDF||324K||Table S2. List of all the mutations identified in our sample by the complete mtDNA sequencing.|
Table S3. mtDNA mutations found in our study and previously associated with diseases.
Table S4. Distribution of 90+ and controls from different centers participating in the GEHA project.
Table S5. Sample distribution and general characteristics of the study participants.
Table S6. Modified primer pairs for complete resequencing.
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